Antihypertnesive Drug:
Ganglion blocking agents:
these drugs blocks the transmission in the autonomic ganglia (either sympathetic or parasympathetic) but we don't currently use these drugs, because of the large adverse reactions resulted from them (e.g., Trimetaphan).
Adrenergic neuron Blocking:
These agents prevent the release of norepinephrin and they reduce the contraction of the smooth muscle (e.g., Debrisoquine)
they are not commonly used.
Drugs that interfere with norepinephrine storage (Reserpine):
They are commonly used in practice although they cause reduction or depletion of norepinephrin. As a result; they reduce the peripheral vascular resistance. They affect the Central Nervous system causing Sedation, depression, Parkinson- Like Syndrome and Postural hypotension which is also common.
Adrenoceptor antagonists or blcokers:
they antagonize the action of catecholamine at alpha and beta receptors
what do they do?
they reduce the cardiac output
they reduce the sympathetic outflow from the central nervaous system
they interfere with "renin" releasing from the kideny, so they reduce "angiotensin" production which means less vasoconstrictive effects.
they are classified into:
alpha blockers:
like prazocine, doxazosin, and Terazosin
beta blcokers:
selective agents (beta 1) Atenolol, Metoprolol they are used commonly in clinical Practice
NonSelective Beta Blockers: Propronolol
proprolol is the commonest drugs in this group
Ganglion blocking agents:
these drugs blocks the transmission in the autonomic ganglia (either sympathetic or parasympathetic) but we don't currently use these drugs, because of the large adverse reactions resulted from them (e.g., Trimetaphan).
Adrenergic neuron Blocking:
These agents prevent the release of norepinephrin and they reduce the contraction of the smooth muscle (e.g., Debrisoquine)
they are not commonly used.
Drugs that interfere with norepinephrine storage (Reserpine):
They are commonly used in practice although they cause reduction or depletion of norepinephrin. As a result; they reduce the peripheral vascular resistance. They affect the Central Nervous system causing Sedation, depression, Parkinson- Like Syndrome and Postural hypotension which is also common.
Adrenoceptor antagonists or blcokers:
they antagonize the action of catecholamine at alpha and beta receptors
what do they do?
they reduce the cardiac output
they reduce the sympathetic outflow from the central nervaous system
they interfere with "renin" releasing from the kideny, so they reduce "angiotensin" production which means less vasoconstrictive effects.
they are classified into:
alpha blockers:
like prazocine, doxazosin, and Terazosin
beta blcokers:
selective agents (beta 1) Atenolol, Metoprolol they are used commonly in clinical Practice
NonSelective Beta Blockers: Propronolol
proprolol is the commonest drugs in this group
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